Buy Ambien (Zolpidem) Insomnia Treatment Online

Medication Name:	Zolpidem (brand: Ambien)
Dosage:	10 mg
Price:	from $2.85 per pill
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Ambien is a hypnotic drug of imidazopyridine structure with a rapid onset effect. Unlike benzodiazepines, zolpidem (active ingredient) is a selective agonist of the omega1-benzodiazepine receptor subclass.

Indications for Ambien

The presence of any contraindications to using and the urgency of an active substance must be individually assessed before using the medicine to prevent adverse consequences and adverse reactions.

The general indicated uses include the following:

• therapy of disorders of circadian rhythms;
• disturbances in falling and waking up;
• often waking up during the night;
• insomnia of long-standing with the development of neurologic symptoms.

How to use: dosage and course of treatment

Ambien is taken by mouth (right before bedtime) at a single dose of 10 mg.

For elderly or debilitated individuals, in cases of hepatic impairment, therapy is initiated at a 5 mg dose.

If the clinical effect is insufficient and tolerated, a dose of 10 mg may increase. The maximal daytime dose is 10 mg. The course of therapy shall last no longer than 4 weeks.

In the case of short-term insomnia, a recommended treatment period is 2-5 days, in the case of situational insomnia - 2-3 weeks. Short treatment intervals do generally do without the necessity of drug withdrawal. In the case of long-term administration of a drug to decrease the likelihood of ricochet insomnia, withdrawal must be done gradually (first, a reduction in daily dose and then drug discontinuation).

Special instructions

Persistent Insomnia for 7-14 days of therapy suggests primary psychiatric disorders and/or nervous disorders. Thus, to identify these disturbances, they should be reassessed regularly.

To decrease the risks of anterograde anemia, the patients must have the conditions for a 7-8-hour of continuous sleep.

Mental and behavioral (including paradoxical) effects may appear with Ambien (the development risk of such effects is greater in older patients). In case of the occurrence of these reactions, Ambien use should be stopped. After course treatment for a few weeks, a certain reduction in the sedative and soporific effect of Ambien is likely.

The administration of Ambien (especially prolonged use) can lead to the formation of a physical and/or psychological addiction, the risks of which are increased with an increase in the dosage and the duration of therapy, as in patients with a history of abuse of aluminum or other medicines and non-drug substances.

These patients must be carefully observed throughout therapy. However, dependence (very rarely) can occur at the use of treatment dosages and/or in individuals without any individual patient risk factors.

Caution should be taken when administering Ambien to older adults due to the risk of severe sedative and/or relaxant symptoms.

During treatment, one should avoid potentially dangerous types of activity requiring high concentration of mind (driving, working with machines) and rapid reaction.

Pharmacodynamics and kinetics

Ambien shares properties with the benzodiazepines. It has a hypnotic, amnestic, anti-convulsant, anxiolytic, sedative effect.

The main active substance affects the benzodiazepine receptors of type I and type II. The product facilitates the opening of the neuronal anion channel via GABA receptors, which increases chloride current.

The interaction is selective, so the effect of the drug directly depends on the dose taken. This makes it possible to achieve amnestic, anxiolytic, and muscle relaxant effects at lower doses in the absence of a hypnotic effect.

The medicine improves sleep quality, accelerates falling asleep, and normalizes the processes of the timely onset of various stages of sleep. As a rule, drowsiness does not persist after waking up. After 30-180 minutes, depending on the rate of absorption, the active substance reaches its maximum level in the blood.

Almost all Ambien binds to plasma proteins, and the drug's bioavailability is up to 70%. In the liver tissue, the drug undergoes a metabolic reaction, forming 3 inactive metabolites. Half of them are excreted in the urine and about 40% in the feces. The half-life is 150 minutes. If the patient has serious liver disorders, the elimination process is extended to 10 hours.